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Embattled Senate Republican Leader Trent Lott remains defiant about hanging on to his post after a GOP colleague declares he is willing to challenge Lott for the leadership job. Sen. Bill Frist (R-TN) has the public support of several GOP senators. Hear NPR's David Welna.

A DC-based public defender and her Jan. 6 defendants take on America’s epidemic of division.

Poet Tracy K. Smith's three favorite poems of 2011 blur the private and public, the personal and political, and will refresh how you look at language and the world.

NPR's Melissa Block reflects on the results of an annual survey about what most scares Americans. The nation's health care system, pollution and another world war rank in the top 10.

Former Vice President Joe Biden was steadier than in past debates; South Bend, Ind., Mayor Pete Buttigieg came under attack; and the candidates defended their least diverse debate stage yet.

Buffalo based M&T Bank is number one in the Northeast for small business banking satisfaction according to the latest study by J.D. Power. Bob Neuhaus,…

Bloomberg Businessweek is out with its annual ranking of Best Business Schools 2016 in the United States. The only local school to make the list of 87 is…

When it comes to wine, some consumers still equate quality with price. But at the 28th Annual International Eastern Wine Competition, a $1.99 bottle of California Wine, the 2002 Charles Shaw Shiraz, beat out 2,300 wines to win a prestigious double gold medal. Hear NPR's Steve Inkseep.

Obama's supporter and former South Dakota Senator Tom Daschle was nominated to be secretary of the Department of Health and Human Services and director of the new White House Office of Health Reform.

Top leaders in Kandahar province in Afghanistan have been assassinated two days before the country votes in parliamentary elections. The top U.S. military commander escaped injury. The Taliban have claimed responsibility in the attack.